Current Advances in the Science of Osteosarcoma

This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.

Thoroughly updated and revised, the second edition is a comprehensive and in-depth look at new developments in a rapidly developing field

Edited by two internationally recognized, leading experts on osteosarcoma and sarcoma, the second edition will feature chapters written by a collection of internationally-based researchers

Provides a comprehensive and up-to-date overview of the current research on the molecular, biological and genetic characteristics of sarcoma and osteosarcoma with in-depth discussions on new developments and future directions