Tumor Suppressor Par-4

Par-4 is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in other diseases, such as Alzheimer’s and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells.

Provides researchers and clinicians with new insights into potential drug discovery and development for various cancers and other human diseases

Describes the role of Par-4 in diverse diseases and their treatment

Highlights novel facets of Par-4 and its role in future clinical trials