www.frohberg.de
Artikel-Detail

Print-Ausgabe

213,99 €
Wählen Sie bitte eine Prämie aus.
sofort lieferbar

Bereits im Bestand

HIV Interactions with Host Cell Proteins

Current Topics in Microbiology and Immunology Vol. 339

Beschreibung

The authors seek to understand the assembly process of human immunodeficiency virus (HIV) and to develop a vaccine that can effectively neutralize HIV. HIV assembly is a process directed by the viral Gag polyprotein. Gag is a myristoylated precursor protein that is translated in the cytoplasm and then traffics to the plasma membrane or to endosomal vesicles for assembly. The authors have recently described an interaction between Gag and the delta subunit of the AP-3 adaptor protein complex (1). The mechanism and structural basis for this interaction is now under intense study. Our hypothesis is that the AP-3 interaction is responsible for the trafficking of Gag to the multivesicular body (MVB) and that this event is part of a normal productive particle assembly pathway. The Vpu protein of HIV assists the virus assembly process through a poorly-defined mechanism. The authors have presented evidence that Vpu overcomes a host cell restriction to assembly (2). Vpu appears to act through interactions with the recycling pathways in the cell, rather than directly interacting with Gag (3). The nature of the host restriction to assembly that Vpu overcomes is a focus of our ongoing work.
weiterlesen

Newsletter

frohberg-Newseltter

Gratis für Sie!

Melden Sie sich jetzt für den frohberg-Newsletter an und sichern sich so Ihre Beatmungsmaske Rescue Me als Dankeschön!

Zum Newsletter

Diese Artikel könnten Sie auch interessieren