Glucose-sensing Receptor in Pancreatic Beta-cells

Since the 1970s, there has been much discussion about the 'glucoreceptor' and 'substrate site' and which of these two is the dominant theory, but new findings on the glucose-sensing receptor have now shed new light on the 'glucoreceptor theory.'

This volume reviews recent advances concerning the glucose-sensing receptor in pancreatic beta-cells.

The history of research into pancreatic beta-cells is long and complex; accordingly, the first chapters present the history of this field and explain the hypothesis of insulin secretion mechanisms: 'glucoreceptor theory'.

Subsequent chapters examine the function and activity of the glucose-sensing receptor in pancreatic beta-cells, such as identification, channel pathway, receptor signal and physiological role. Readers will gain a thorough understanding of the glucose-sensing receptor and glucose metabolism in pancreatic beta-cells, new insights into the pathophysiology of diabetes, and learn about new targets for the treatment of diabetes. 

Itaru Kojima, M.D. Professor Emeritus                                               

Institute for Molecular & Cellular Regulation, Gunma University