5-HT2A receptors are G-protein coupled receptors that are widely distributed throughout the brain, most notably on neuronal and glial cells. 5-HT2A receptors have been implicated in various central physiological functions including mood regulation, memory, sleep, nociception, eating, and reward behaviors, and they are also believed to control the cardiovascular system. This book provides a comprehensive overview of these receptors including sections on their properties and distribution, approaches for their study, their role in a number of brain functions and diseases, and their role as therapeutic targets. ?Giuseppe Di Giovanni
is Professor of Human Physiology, University of Malta, Malta. He is the President of the Malta Neuroscience Network and the Vice-President of the Mediterranean Neuroscience Society. He is the Editor in Chief of Journal Neuroscience Methods by Elsevier and the Editor for the book series The Receptor by Springer/Nature. His research focuses on the pathophysiology of the monoaminergic systems in different neuropsychiatric disorders, such as Parkinson's disease, depression, drug of abuse and epilepsy.
Bruno Guiard is Associate Professor in Pharmacology, University of Paris XI, France. He is the author of several book chapters/reviews on the mechanisms of action of antidepressant drugs. He also took part in the edition of books on the neurobiology of mood. His research deals with the influence of astroglial cells in the regulation of serotonergic neurotransmission and the identification of new pharmacological targets for the treatment of various neuropsychiatric diseases.