Hormones, Intrauterine Health and Programming

The authors address in particular the role of hormones and their links with other maternal environmental mediators in developmental programming. The crucial nature of the placenta as an interface and target between maternal and foetal environments is addressed. Emphasis is made on the emerging science of epigenetics as a potential explanation for how environmental events that occur during brief windows of development may exert effects that impact upon somatic cells through many rounds of mitosis for much of the life span of the subsequent organism.

Jonathan Seckl is a Professor of Molecular Medicine at the University of Edinburgh, Endocrinology Unit, Centre for Cardiovascular Science at Queen's Medical Research Institute.