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Histiocytic Neoplasms and Related Disorders

Print-on-Demand Ausgabe

Print-Ausgabe

2017


This volume provides a comprehensive and world-class review of the field of histiocytic neoplasms and hemophagocytic lymphohistiocytosis (HLH). It reviews all the advances in the field of histiocytosis during the last ten years, particularly with regards to the genomic findings in LCH and other histiocytic neoplasms, the new suggested classification of the histiocytic disorders, and the most recent genetic and pathophysiological findings of primary and secondary HLH, including the macrophage-activating syndrome (MAS). Additionally, it features a state-of-the art update on the most recent treatment strategies for LCH, including the results of the last LCH-III international trial, salvage therapies such as reduced-intensity conditioning (RIC) stem cell transplant (SCT), and targeted therapies with BRAF and MEK inhibitors, as well as the challenging cases of CNS-neurodegenerative LCH and its therapeutic perspectives. The text also highlights the most recent advances in the treatment of the uncommon histiocytic disorders, such as ECD, JXG, and Rosai-Dorfman disease (RDD).Written by international experts in the field, Histiocytic Neoplasms and Related Disorders is a valuable resource for clinicians, researchers, and residents who are interested in or manage histiocytic disorders in children and adults.

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