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Primer on the HLA-System

Basic Concepts - Medical Relevance - Laboratory Methods - Quality Management


The human leukocyte antigen (HLA) system comprises a complex, highly diverse, genetic group of molecules that play a pivotal role in immunobiology and which are of tremendous medical importance. This primer seeks to provide clinicians and researchers with a fundamental understanding of the immunological concepts underlying the HLA system and their medical significance. It also serves as an introduction to the relevant diagnostic procedures and addresses practical aspects of organizing and running an HLA laboratory, including quality management. From the content: Basic concepts of the HLA system, tissue typing and histocompatibility testing Relevance of the HLA system for transplantation, transfusion, and cancer as well as its association with diseases Serological and molecular methods for tissue typing and histocompatibility testing Quality management in daily laboratory practice



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